Korennykh Lab

Protein levels in mammalian cells are set largely by the abundance of their messenger RNAs (mRNAs). The mRNA abundance depends on mRNA production and decay, which change according to the needs of the cell. The production is controlled by transcription factors or by chromatin modifications epigenetically, whereas decay is controlled by microRNAs (miRNAs), by proteins that bind to AU-rich RNA elements (AREs) in mRNAs, as well as by poly-U tail addition or m6A methylation...