Gavis Lab

Confocal projection of the posterior pole of an early Drosophila embryo.
Principal Investigator
Elizabeth R. Gavis
Schultz Laboratory, 416
RNA localization and translational regulation during development in Drosophila

Subcellular mRNA localization and translational control in Drosophila development

Localization of proteins to particular regions of cells or tissues is fundamental to the generation of asymmetry during early development and the polarized functions of differentiated cells like neurons. In many cell types, protein synthesis can be targeted to sites where proteins are needed through the localization of their mRNAs. Furthermore, coupling of mRNA localization to translational control restricts protein synthesis to the target destination. Our lab studies the cellular and biochemical mechanisms of mRNA localization and localization-dependent translational control during oogenesis, embryogenesis, and neuronal development in Drosophila melanogaster.