Flint Lab

Like all viruses, human adenoviruses are molecular parasites that rely on cellular mechanisms for expression of their genetic information. They are therefore excellent model systems for investigation of fundamental cellular processes. Furthermore, several adenoviral genes can contribute to neoplastic transformation of cells in culture and certain adenovirus serotypes are tumorigenic in laboratory animals. Study of these oncogenic viral gene products has provided important insights into the mechanisms that regulate progression through the cell cycle...