Publications
Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in . ACS Chem Biol. 2022 ;17(8):2332-2343.
. Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs). Biochemistry. 2023 ;62(2):201-209.
. MHC class I limits hippocampal synapse density by inhibiting neuronal insulin receptor signaling. J Neurosci. 2014 ;34(35):11844-56.
. The life of a microtubule. Mol Biol Cell. 2018 ;29(6):689.
. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 ;167(7):1853-1866.e17.
. A comprehensive genome-scale model for IFO0880 accounting for functional genomics and phenotypic data. Metab Eng Commun. 2019 ;9:e00101.
. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018 ;115(27):E6310-E6318.
. Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. mBio. 2018 ;9(3).
. Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Sci Adv. 2021 ;7(47):eabk1023.
. Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles. Proc Natl Acad Sci U S A. 2017 ;114(5):1147-1152.
. Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo. J Virol. 2017 ;91(4).
. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015 ;11(1):787.
. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Mol Cell Proteomics. 2015 ;14(9):2341-56.
. Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing. Cell Host Microbe. 2015 ;18(3):270-2.
. . Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst. 2018 ;6(6):655-663.e5.
. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021 ;35(12):109280.
. Optogenetic Reconstitution for Determining the Form and Function of Membraneless Organelles. Biochemistry. 2018 ;57(17):2432-2436.
. Reductio ad Intellectum. Annu Rev Virol. 2018 ;5(1):ii-iv.
. A New Coronavirus Emerges, This Time Causing a Pandemic. Annu Rev Virol. 2020 ;7(1):iii-v.
. The cell biology of aging. Mol Biol Cell. 2015 ;26(25):4524-31.
. A protein constructed de novo enables cell growth by altering gene regulation. Proc Natl Acad Sci U S A. 2016 ;113(9):2400-5.
. A Non-natural Protein Rescues Cells Deleted for a Key Enzyme in Central Metabolism. ACS Synth Biol. 2017 ;6(4):694-700.
. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proc Natl Acad Sci U S A. 2019 ;116(44):22152-22157.
. Chromatin as a key consumer in the metabolite economy. Nat Chem Biol. 2020 ;16(6):620-629.
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