Publications
Inhibitor Mimetic Mutations in the PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. ACS Chem Biol. 2021 ;16(4):740-752.
. Integrative analysis unveils new functions for the Cutoff protein in noncoding RNA biogenesis and gene regulation. RNA. 2017 ;23(7):1097-1109.
. Integrin-dependent anchoring of a stem-cell niche. Nat Cell Biol. 2007 ;9(12):1413-8.
. Kel1p Mediates Yeast Cell Fusion Through a Fus2p- and Cdc42p-Dependent Mechanism. Genetics. 2016 ;202(4):1421-35.
. Low-variance RNAs identify Parkinson's disease molecular signature in blood. Mov Disord. 2015 ;30(6):813-21.
. The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation. Biophys J. 2013 ;104(11):2401-9.
. Mechanisms and causality in molecular diseases. Hist Philos Life Sci. 2017 ;39(4):35.
. Mechanistic insights into the cellular effects of a novel FN1 variant associated with a spondylometaphyseal dysplasia. Clin Genet. 2018 ;94(5):429-437.
. Membrane curvature directs the localization of Cdc42p to novel foci required for cell-cell fusion. J Cell Biol. 2017 ;216(12):3971-3980.
. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021 ;3(11):1512-1520.
. Mitochondria and Cancer. Mol Cell. 2016 ;61(5):667-676.
. Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat Cell Biol. 2011 ;13(8):893-902.
. Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. J Am Chem Soc. 2012 ;134(33):13550-3.
. Molecular mechanisms underlying cellular effects of human MEK1 mutations. Mol Biol Cell. 2021 ;32(9):974-983.
. MreB Orientation Correlates with Cell Diameter in Escherichia coli. Biophys J. 2016 ;111(5):1035-43.
. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022 ;55(1):65-81.e9.
. mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. Mol Cell. 2017 ;67(6):936-946.e5.
. . Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals. Development. 2016 ;143(12):2147-59.
. Network-Based Coverage of Mutational Profiles Reveals Cancer Genes. Cell Syst. 2017 ;5(3):221-229.e4.
. Novel RpoS-Dependent Mechanisms Strengthen the Envelope Permeability Barrier during Stationary Phase. J Bacteriol. 2017 ;199(2).
. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021 ;17(4):403-411.
. Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. Mol Cell. 2022 ;82(16):2925-2938.
. Optimizing photoswitchable MEK. Proc Natl Acad Sci U S A. 2019 ;116(51):25756-25763.
. orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET. Nature. 2013 ;498(7455):487-91.
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