Publications
Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. Nat Chem Biol. 2018 ;14(9):837-840.
. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016 ;352(6287):844-9.
. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021 ;373(6552):306-315.
. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
. Janus Bioparticles: Asymmetric Nucleosomes and Their Preparation Using Chemical Biology Approaches. Acc Chem Res. 2021 ;54(16):3215-3227.
. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nat Chem Biol. 2016 ;12(3):188-93.
. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2020 ;77(3):501-513.e7.
. The expanding landscape of 'oncohistone' mutations in human cancers. Nature. 2019 ;567(7749):473-478.
. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 ;40(4):645-57.
. Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype. Proc Natl Acad Sci U S A. 2017 ;114(39):E8244-E8253.
. Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor. Cell Host Microbe. 2017 ;21(6):731-741.e10.
. Metabolic control of methylation and acetylation. Curr Opin Chem Biol. 2016 ;30:52-60.
. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Nat Commun. 2018 ;9(1):4310.
. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017 ;24(12):1028-1038.
. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018 ;9(1):1394.
. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021 ;118(27).
. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 ;369(6502):397-403.
. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021 ;118(6).
. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun. 2016 ;7:10589.
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