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2018
Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, et al. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018 ;115(52):13347-13352.
Guan D, Xiong Y, Borck PC, Jang C, Doulias P-T, Papazyan R, et al. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018 ;174(4):831-842.e12.
Gu Y, Lewallen S, Kinkhabwala AA, Domnisoru C, Yoon KJ, Gauthier JL, et al. A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex. Cell. 2018 ;175(3):736-750.e30.
Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, et al. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 2018 ;7.
Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, et al. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018 ;10(447).
Douam F, Fusil F, Enguehard M, Dib L, Nadalin F, Schwaller L, et al. A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism. PLoS Pathog. 2018 ;14(3):e1006908.
Liu L, Su X, Quinn WJ, Hui S, Krukenberg K, Frederick DW, et al. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018 ;27(5):1067-1080.e5.
Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, et al. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018 ;27(2):351-361.e3.
Marvin JS, Scholl B, Wilson DE, Podgorski K, Kazemipour A, Müller JAlexander, et al.. Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR. Nat Methods. 2018 ;15(11):936-939.
Yan R, Zhang J, Park H-J, Park ES, Oh S, Zheng H, et al. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB. Proc Natl Acad Sci U S A. 2018 ;115(51):E12053-E12062.
Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, et al. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018 ;24(4):518-524.
2017
Meshulam L, Gauthier JL, Brody CD, Tank DW, Bialek W. Collective Behavior of Place and Non-place Neurons in the Hippocampal Network. Neuron. 2017 ;96(5):1178-1191.e4.
Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, et al. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. PLoS One. 2017 ;12(12):e0189413.
Zhang Y, Kurupati R, Liu L, Zhou XYang, Zhang G, Hudaihed A, et al. Enhancing CD8 T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017 ;32(3):377-391.e9.
Kim HIn, Raffler J, Lu W, Lee J-J, Abbey D, Saleheen D, et al. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017 ;101(4):489-502.
Pomeranz LE, Ekstrand MI, Latcha KN, Smith GA, Enquist LW, Friedman JM. Gene Expression Profiling with Cre-Conditional Pseudorabies Virus Reveals a Subset of Midbrain Neurons That Participate in Reward Circuitry. J Neurosci. 2017 ;37(15):4128-4144.
Cervantes-Barragan L, Chai JN, Tianero MDiarey, Di Luccia B, Ahern PP, Merriman J, et al. induces gut intraepithelial CD4CD8αα T cells. Science. 2017 ;357(6353):806-810.
Celià-Terrassa T, Liu DD, Choudhury A, Hang X, Wei Y, Zamalloa J, et al.. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol. 2017 ;19(6):711-723.
Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MChun, et al. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circ Res. 2017 ;121(12):1370-1378.
2016
Rosario W, Singh I, Wautlet A, Patterson C, Flak J, Becker TC, et al. The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. 2016 ;65(9):2711-23.
Cope EC, Briones BA, Brockett AT, Martinez S, Vigneron P-A, Opendak M, et al. Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism. eNeuro. 2016 ;3(5).
Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chem Biol. 2016 ;11(9):2420-7.
Frederick DW, Loro E, Liu L, Davila A, Chellappa K, Silverman IM, et al. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 ;24(2):269-82.
Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, et al. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 ;24(1):104-17.
Papazyan R, Sun Z, Kim YHoon, Titchenell PM, Hill DA, Lu W, et al. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016 ;24(6):863-874.