Publications
HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016 ;35(13):1385-99.
. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018 ;360(6396).
. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019 ;20(1):50-63.
. Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nat Immunol. 2019 ;20(8):1023-1034.
. Serine Metabolism Supports Macrophage IL-1β Production. Cell Metab. 2019 ;29(4):1003-1011.e4.
. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 ;16(7):731-739.
. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. 2021 ;590(7844):122-128.
. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022 ;39(3):110714.
. Tumor-derived Jagged1 promotes cancer progression through immune evasion. Cell Rep. 2022 ;38(10):110492.
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