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2021
Schröder HV, Zhang Y, A Link J. Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides. Nat Chem. 2021 ;13(9):850-857.
Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, et al. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 ;118(3).
Caruso A, Seyedsayamdost MR. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021 ;86(16):11284-11289.
2020
Zhang C, Seyedsayamdost MR. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020 ;15(4):890-894.
Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, et al. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020 ;22(6):674-688.
Jiang X, Yuan Y, Huang J, Zhang S, Luo S, Wang N, et al. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020 ;183(1):258-268.e12.
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, et al. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020 ;182(1):98-111.e18.
Seo KW, Kleiner RE. YTHDF2 Recognition of N-Methyladenosine (mA)-Modified RNA Is Associated with Transcript Destabilization. ACS Chem Biol. 2020 ;15(1):132-139.
2019
Clark KA, Bushin LB, Seyedsayamdost MR. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019 ;141(27):10610-10615.
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, et al. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019 ;576(7787):492-497.
Caruso A, Martinie RJ, Bushin LB, Seyedsayamdost MR. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical -Adenosylmethionine Enzymes. J Am Chem Soc. 2019 ;141(42):16610-16614.
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, et al. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019 ;177(6):1495-1506.e12.
Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, et al. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019 ;363(6433):1309-1313.
Cheung-Lee WLing, Cao L, A Link J. Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. ACS Chem Biol. 2019 ;14(12):2783-2792.
Piscotta FJ, Jeffrey PD, A Link J. ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Proc Natl Acad Sci U S A. 2019 ;116(3):826-834.
Caruso A, Bushin LB, Clark KA, Martinie RJ, Seyedsayamdost MR. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019 ;141(2):990-997.
Valencia AM, Collings CK, Dao HT, St Pierre R, Cheng Y-C, Huang J, et al. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019 ;179(6):1342-1356.e23.
Wang S-W, Bitbol A-F, Wingreen NS. Revealing evolutionary constraints on proteins through sequence analysis. PLoS Comput Biol. 2019 ;15(4):e1007010.
Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 ;363(6433):1303-1308.
Carabetta VJ, Greco TM, Cristea IM, Dubnau D. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019 ;116(9):3752-3757.
2018
Zong C, Cheung-Lee WLing, Elashal HE, Raj M, A Link J. Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chem Commun (Camb). 2018 ;54(11):1339-1342.
Hecht MH, Zarzhitsky S, Karas C, Chari S. Are natural proteins special? Can we do that?. Curr Opin Struct Biol. 2018 ;48:124-132.
Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW. An Atypical Mechanism of Split Intein Molecular Recognition and Folding. J Am Chem Soc. 2018 ;140(37):11791-11799.
Bushin LB, Clark KA, Pelczer I, Seyedsayamdost MR. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018 ;140(50):17674-17684.
Wojcik F, Dann GP, Beh LY, Debelouchina GT, Hofmann R, Muir TW. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018 ;9(1):1394.