Publications
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Synthesis of Oriented Hexasomes and Asymmetric Nucleosomes Using a Template Editing Process. J Am Chem Soc. 2022 ;144(5):2284-2291.
. Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 ;118(11).
. Engineering of a Peptide α-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids. Angew Chem Int Ed Engl. 2021 ;60(26):14319-14323.
. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 ;118(3).
. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021 ;35(13):109299.
. Structural insights into RNA polymerases of negative-sense RNA viruses. Nat Rev Microbiol. 2021 ;19(5):303-318.
. Structure of human Ca2.2 channel blocked by the painkiller ziconotide. Nature. 2021 ;596(7870):143-147.
. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021 ;118(11).
. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 ;117(31):18497-18503.
. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020 ;117(25):14187-14193.
. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
. . Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020 ;117(48):30465-30475.
. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019 ;576(7787):492-497.
. Discovery and structure of the antimicrobial lasso peptide citrocin. J Biol Chem. 2019 ;294(17):6822-6830.
. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019 ;26(4):548-558.e4.
. Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. J Proteome Res. 2019 ;18(5):1929-1938.
. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019 ;363(6433):1309-1313.
. Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. ACS Chem Biol. 2019 ;14(12):2783-2792.
. Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L. Proc Natl Acad Sci U S A. 2019 ;116(6):2103-2111.
. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019 ;10(1):888.
. Structural Insights into the Mechanism of Dynamin Superfamily Proteins. Trends Cell Biol. 2019 ;29(3):257-273.
. Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc Natl Acad Sci U S A. 2019 ;116(4):1273-1278.
. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 ;363(6433):1303-1308.
. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019 ;116(9):3752-3757.
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