Publications
c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Rep. 2016 ;14(8):1841-9.
. Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. mBio. 2019 ;10(4).
. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol. 2020 ;38(8):954-961.
. CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing. J Virol. 2021 ;95(6).
. CROTON: an automated and variant-aware deep learning framework for predicting CRISPR/Cas9 editing outcomes. Bioinformatics. 2021 ;37(Suppl_1):i342-i348.
. Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nat Biotechnol. 2021 ;39(11):1414-1425.
. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021 ;184(22):5635-5652.e29.
. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017 ;101(4):489-502.
. Generation of Large Fragment Knock-In Mouse Models by Microinjecting into 2-Cell Stage Embryos. Methods Mol Biol. 2020 ;2066:89-100.
. Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet. 2015 ;49:21-45.
. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014 ;159(3):647-61.
. Genomic targeting of epigenetic probes using a chemically tailored Cas9 system. Proc Natl Acad Sci U S A. 2017 ;114(4):681-686.
. Massively multiplexed nucleic acid detection with Cas13. Nature. 2020 ;582(7811):277-282.
. A multifaceted signal recorder of cellular experiences using Cas12a base-editing. Trends Biotechnol. 2022 ;40(11):1279-1281.
. Programmable Inhibition and Detection of RNA Viruses Using Cas13. Mol Cell. 2019 ;76(5):826-837.e11.
. Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proc Natl Acad Sci U S A. 2017 ;114(1):131-135.
. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016 ;23(6):1140-1153.
. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021 ;371(6532).
. Uncoupling neurogenic gene networks in the embryo. Genes Dev. 2017 ;31(7):634-638.
. Using RNA Tags for Multicolor Live Imaging of Chromatin Loci and Transcription in Drosophila Embryos. Methods Mol Biol. 2020 ;2166:373-384.
. What are the current bottlenecks in developing and applying CRISPR technologies?. Cell Syst. 2022 ;13(8):589-593.
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