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2022
Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown EJ, et al. G6PD-mediated increase in de novo NADP biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv. 2022 ;8(29):eabo0404.
Du J, Estrella M, Solorio-Kirpichyan K, Jeffrey PD, Korennykh A. Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria. Proc Natl Acad Sci U S A. 2022 ;119(26):e2200923119.
2021
Schild T, McReynolds MR, Shea C, Low V, Schaffer BE, Asara JM, et al. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021 ;35(11):109238.
Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, et al. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021 ;3(12):1608-1620.
2020
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, et al.. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 ;16(7):731-739.
2019
Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 ;1:404-415.
2018
Lu W, Wang L, Chen L, Hui S, Rabinowitz JD. Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors. Antioxid Redox Signal. 2018 ;28(3):167-179.
2017
Zhang Z, Chen L, Liu L, Su X, Rabinowitz JD. Chemical Basis for Deuterium Labeling of Fat and NADPH. J Am Chem Soc. 2017 ;139(41):14368-14371.
Lu W, Su X, Klein MS, Lewis IA, Fiehn O, Rabinowitz JD. Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. Annu Rev Biochem. 2017 ;86:277-304.
2016
Liu L, Shah S, Fan J, Park JO, Wellen KE, Rabinowitz JD. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nat Chem Biol. 2016 ;12(5):345-52.
Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, et al. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016 ;23(6):1140-1153.
Gowers G-OF, Robinson JL, Brynildsen MP. Starved Escherichia coli preserve reducing power under nitric oxide stress. Biochem Biophys Res Commun. 2016 ;476(1):29-34.