Publications
G6PD-mediated increase in de novo NADP biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv. 2022 ;8(29):eabo0404.
. Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria. Proc Natl Acad Sci U S A. 2022 ;119(26):e2200923119.
. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021 ;35(11):109238.
. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021 ;3(12):1608-1620.
. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 ;16(7):731-739.
. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 ;1:404-415.
. Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors. Antioxid Redox Signal. 2018 ;28(3):167-179.
. Chemical Basis for Deuterium Labeling of Fat and NADPH. J Am Chem Soc. 2017 ;139(41):14368-14371.
. Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. Annu Rev Biochem. 2017 ;86:277-304.
. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nat Chem Biol. 2016 ;12(5):345-52.
. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016 ;23(6):1140-1153.
. Starved Escherichia coli preserve reducing power under nitric oxide stress. Biochem Biophys Res Commun. 2016 ;476(1):29-34.
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