Publications
] . Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 ;10(1):2320.
. Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L. Proc Natl Acad Sci U S A. 2019 ;116(6):2103-2111.
. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019 ;10(1):888.
. Systematic domain-based aggregation of protein structures highlights DNA-, RNA- and other ligand-binding positions. Nucleic Acids Res. 2019 ;47(2):582-593.
. A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters. J Mol Biol. 2017 ;429(17):2710-2725.
. Human CTP synthase filament structure reveals the active enzyme conformation. Nat Struct Mol Biol. 2017 ;24(6):507-514.
. Structure of the Human Lipid Exporter ABCA1. Cell. 2017 ;169(7):1228-1239.e10.
. Structure of the Nav1.4-β1 Complex from Electric Eel. Cell. 2017 ;170(3):470-482.e11.
. The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. 2016 ;26(9):995-1006.
. Design of a Split Intein with Exceptional Protein Splicing Activity. J Am Chem Soc. 2016 ;138(7):2162-5.
. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun. 2016 ;7:10589.
. GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters. Protein Sci. 2016 ;25(3):546-58.
. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 ;167(7):1867-1882.e21.
. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nat Chem Biol. 2016 ;12(3):188-93.
. An Amphiphysin-Like Domain in Fus2p Is Required for Rvs161p Interaction and Cortical Localization. G3 (Bethesda). 2015 ;6(2):337-49.
. Biosynthesis: Leading the way to RiPPs. Nat Chem Biol. 2015 ;11(8):551-2.
. Elucidating the Specificity Determinants of the AtxE2 Lasso Peptide Isopeptidase. J Biol Chem. 2015 ;290(52):30806-12.
. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015 ;526(7573):391-6.
. Outer membrane lipoprotein biogenesis: Lol is not the end. Philos Trans R Soc Lond B Biol Sci. 2015 ;370(1679).
. Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso. Mol Cell. 2015 ;60(6):941-52.
. Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3. Proc Natl Acad Sci U S A. 2015 ;112(13):3949-54.
. Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink. Nat Chem. 2015 ;7(5):431-437.
. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature. 2015 ;517(7532):50-55.
. Crystal structure of a bacterial homologue of SWEET transporters. Cell Res. 2014 ;24(12):1486-9.
. Crystal structure of the human glucose transporter GLUT1. Nature. 2014 ;510(7503):121-5.