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2021
Mashtalir N, Dao HT, Sankar A, Liu H, Corin AJ, Bagert JD, et al. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021 ;373(6552):306-315.
Pan X, Li Z, Jin X, Zhao Y, Huang G, Huang X, et al. Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 ;118(11).
Landajuela A, Braun M, Rodrigues CDA, Martínez-Calvo A, Doan T, Horenkamp F, et al.. FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. PLoS Biol. 2021 ;19(6):e3001314.
Li Z, Jin X, Wu T, Huang G, Wu K, Lei J, et al. Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na 1.5 by the Antiarrhythmic Drug Quinidine*. Angew Chem Int Ed Engl. 2021 ;60(20):11474-11480.
Gao S, Yao X, Yan N. Structure of human Ca2.2 channel blocked by the painkiller ziconotide. Nature. 2021 ;596(7870):143-147.
Li Z, Jin X, Wu T, Zhao X, Wang W, Lei J, et al. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021 ;118(11).
2020
Stadlmeier M, Runtsch LSimon, Streshnev F, Wühr M, Carell T. A Click-Chemistry-Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry. Chembiochem. 2020 ;21(1-2):103-107.
Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 ;117(31):18497-18503.
Gao S, Valinsky WC, On NCam, Houlihan PR, Qu Q, Liu L, et al. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020 ;117(25):14187-14193.
Statt A, Casademunt H, Brangwynne CP, Panagiotopoulos AZ. Model for disordered proteins with strongly sequence-dependent liquid phase behavior. J Chem Phys. 2020 ;152(7):075101.
McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, et al. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
Leicher R, Ge EJ, Lin X, Reynolds MJ, Xie W, Walz T, et al. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020 ;117(48):30465-30475.
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, et al. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 ;581(7808):333-338.
Travis SM, DAmico K, Yu I-M, McMahon C, Hamid S, Ramirez-Arellano G, et al. Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1. J Biol Chem. 2020 ;295(30):10125-10135.
Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, et al. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020 ;182(1):98-111.e18.
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, et al. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 ;581(7808):329-332.
2019
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, et al. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019 ;576(7787):492-497.
Hart EM, O'Connell A, Tang K, Wzorek JS, Grabowicz M, Kahne D, et al. Fine-Tuning of σ Activation Suppresses Multiple Assembly-Defective Mutations in Escherichia coli. J Bacteriol. 2019 ;201(11).
Taylor CA, Cormier KW, Keenan SE, Earnest S, Stippec S, Wichaidit C, et al. Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc Natl Acad Sci U S A. 2019 ;116(31):15514-15523.
Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, et al.. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proc Natl Acad Sci U S A. 2019 ;116(17):8295-8300.
Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 ;10(1):2320.
Zhang Y, Kleiner RE. A Metabolic Engineering Approach to Incorporate Modified Pyrimidine Nucleosides into Cellular RNA. J Am Chem Soc. 2019 ;141(8):3347-3351.
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, et al. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature. 2019 ;572(7769):347-351.
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, et al. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A. 2019 ;116(51):25575-25582.
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, et al. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019 ;177(6):1495-1506.e12.