Publications
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022 ;55(1):65-81.e9.
. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. 2021 ;590(7844):122-128.
. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020 ;2(11):1284-1304.
. Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses. J Vis Exp. 2020 ;(160).
. Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling. PLoS Pathog. 2019 ;15(11):e1008087.
. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019 ;20(1):50-63.
. A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure. Pediatr Crit Care Med. 2019 ;20(12):1137-1146.
. Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nat Immunol. 2019 ;20(8):1023-1034.
. SIG1459: A novel phytyl-cysteine derived TLR2 modulator with in vitro and clinical anti-acne activity. Exp Dermatol. 2018 ;27(9):993-999.
. .
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 ;24(2):269-82.
. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016 ;24(6):863-874.
. Statistical significance of variables driving systematic variation in high-dimensional data. Bioinformatics. 2015 ;31(4):545-54.
.