Publications
A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing. Nat Chem Biol. 2020 ;16(2):134-142.
. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2020 ;77(3):501-513.e7.
. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020 ;117(48):30465-30475.
. Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding. Genetics. 2019 ;213(2):465-479.
. The expanding landscape of 'oncohistone' mutations in human cancers. Nature. 2019 ;567(7749):473-478.
. Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization. Cell. 2019 ;177(7):1781-1796.e25.
. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019 ;179(6):1342-1356.e23.
. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Nat Commun. 2018 ;9(1):4310.
. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018 ;9(1):1394.
. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. Proc Natl Acad Sci U S A. 2018 ;115(5):E876-E885.
. ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature. 2017 ;548(7669):607-611.
. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017 ;24(12):1028-1038.
. Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and Their Modifications. ACS Chem Biol. 2016 ;11(3):782-91.
. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 ;5.
. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun. 2016 ;7:10589.
. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016 ;352(6287):844-9.
. DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome. Genome Res. 2015 ;25(11):1727-38.
. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proc Natl Acad Sci U S A. 2015 ;112(33):10365-70.
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