Publications
Synthesis of Oriented Hexasomes and Asymmetric Nucleosomes Using a Template Editing Process. J Am Chem Soc. 2022 ;144(5):2284-2291.
. Chemical biology approaches to study histone interactors. Biochem Soc Trans. 2021 ;49(5):2431-2441.
. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021 ;373(6552):306-315.
. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021 ;118(27).
. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021 ;118(6).
. Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning. Nat Genet. 2021 ;53(4):487-499.
. Janus Bioparticles: Asymmetric Nucleosomes and Their Preparation Using Chemical Biology Approaches. Acc Chem Res. 2021 ;54(16):3215-3227.
. Molecular Epigenetics: Chemical Biology Tools Come of Age. Annu Rev Biochem. 2021 ;90:287-320.
. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021 ;17(4):403-411.
. Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction. Nat Commun. 2021 ;12(1):5888.
. Synthesis of ADP-Ribosylated Histones Reveals Site-Specific Impacts on Chromatin Structure and Function. J Am Chem Soc. 2021 ;143(29):10847-10852.
. A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing. Nat Chem Biol. 2020 ;16(2):134-142.
. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2020 ;77(3):501-513.e7.
. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 ;369(6502):397-403.
. Chromatin as a key consumer in the metabolite economy. Nat Chem Biol. 2020 ;16(6):620-629.
. In situ chromatin interactomics using a chemical bait and trap approach. Nat Chem. 2020 ;12(6):520-527.
. Living under Strain: How Epithelia Protect Their Genomes from Repeated Stretching. Biochemistry. 2020 ;59(30):2761-2763.
. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020 ;117(48):30465-30475.
. Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding. Genetics. 2019 ;213(2):465-479.
. The expanding landscape of 'oncohistone' mutations in human cancers. Nature. 2019 ;567(7749):473-478.
. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proc Natl Acad Sci U S A. 2019 ;116(17):8295-8300.
. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019 ;567(7749):535-539.
. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019 ;10(1):5343.
. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019 ;10(1):2146.
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