Publications
The Host Factor ANP32A Is Required for Influenza A Virus vRNA and cRNA Synthesis. J Virol. 2022 ;96(4):e0209221.
. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022 ;55(1):65-81.e9.
. Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. Mol Cell. 2022 ;82(16):2925-2938.
. Chaperoning SNARE Folding and Assembly. Annu Rev Biochem. 2021 ;90:581-603.
. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021 ;373(6552):306-315.
. Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 ;118(11).
. CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing. J Virol. 2021 ;95(6).
. Decoding disease: from genomes to networks to phenotypes. Nat Rev Genet. 2021 ;22(12):774-790.
. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021 ;184(22):5635-5652.e29.
. Enzyme regulation and mutation in a model serial-dilution ecosystem. Phys Rev E. 2021 ;104(4-1):044412.
. Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk. Nat Genet. 2021 ;53(2):166-173.
. Inhibitor Mimetic Mutations in the PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. ACS Chem Biol. 2021 ;16(4):740-752.
. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021 ;3(11):1512-1520.
. Molecular mechanisms underlying cellular effects of human MEK1 mutations. Mol Biol Cell. 2021 ;32(9):974-983.
. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021 ;17(4):403-411.
. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021 ;118(11).
. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 ;371(6533).
. Asymmetry between Activators and Deactivators in Functional Protein Networks. Sci Rep. 2020 ;10(1):10131.
. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2020 ;1(9):923-934.
. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. 2020 ;586(7829):445-451.
. CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020 ;15(4):890-894.
. Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy. Science. 2020 ;369(6499):71-77.
. Differential Allele-Specific Expression Uncovers Breast Cancer Genes Dysregulated by Cis Noncoding Mutations. Cell Syst. 2020 ;10(2):193-203.e4.
. The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling. Mol Cell Proteomics. 2020 ;19(7):1193-1208.
. Functions of the BamBCDE Lipoproteins Revealed by Bypass Mutations in BamA. J Bacteriol. 2020 ;202(21).
.