Publications
Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022 ;665:305-323.
. Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs). J Ind Microbiol Biotechnol. 2021 ;48(3-4).
. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem Biol. 2021 ;16(12):2825-2833.
. A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu Rev Biochem. 2021 ;90:763-788.
. New developments in RiPP discovery, enzymology and engineering. Nat Prod Rep. 2021 ;38(1):130-239.
. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021 ;86(16):11284-11289.
. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J Nat Prod. 2020 ;83(3):738-743.
. Discovery of a Cryptic Depsipeptide from Streptomyces ghanaensis via MALDI-MS-Guided High-Throughput Elicitor Screening. Angew Chem Int Ed Engl. 2020 ;59(51):23005-23009.
. Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PLoS Biol. 2020 ;18(12):e3001026.
. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio. 2020 ;11(1).
. Special Issue in Honor of Professor Jon Clardy. J Nat Prod. 2020 ;83(3):565-568.
. Thailandenes, Cryptic Polyene Natural Products Isolated from Using Phenotype-Guided Transposon Mutagenesis. ACS Chem Biol. 2020 ;15(5):1195-1203.
. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020 ;15(10):2766-2774.
. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019 ;141(27):10610-10615.
. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019 ;85(8).
. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019 ;15(2):161-168.
. Potential of marine natural products against drug-resistant bacterial infections. Lancet Infect Dis. 2019 ;19(7):e237-e245.
. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019 ;46(3-4):301-311.
. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018 ;606:439-460.
. The Polyene Natural Product Thailandamide A Inhibits Fatty Acid Biosynthesis in Gram-Positive and Gram-Negative Bacteria. Biochemistry. 2018 ;57(29):4247-4251.
. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc. 2017 ;139(27):9203-9212.
. Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid. Org Lett. 2017 ;19(19):5138-5141.
. Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chem Biol. 2016 ;23(2):214-224.
. Biosynthesis: Leading the way to RiPPs. Nat Chem Biol. 2015 ;11(8):551-2.
. HUMAN MICROBIOTA. Small molecules from the human microbiota. Science. 2015 ;349(6246):1254766.
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