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2021
Pan X, Li Z, Jin X, Zhao Y, Huang G, Huang X, et al. Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 ;118(11).
Li Z, Jin X, Wu T, Huang G, Wu K, Lei J, et al. Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na 1.5 by the Antiarrhythmic Drug Quinidine*. Angew Chem Int Ed Engl. 2021 ;60(20):11474-11480.
Gong D, Yan N, Ledford HA. Structural Basis for the Modulation of Ryanodine Receptors. Trends Biochem Sci. 2021 ;46(6):489-501.
Gao S, Yan N. Structural Basis of the Modulation of the Voltage-Gated Calcium Ion Channel Ca 1.1 by Dihydropyridine Compounds*. Angew Chem Int Ed Engl. 2021 ;60(6):3131-3137.
Shen H, Yan N, Pan X. Structural determination of human Na v 1.4 and Na v 1.7 using single particle cryo-electron microscopy. Methods Enzymol. 2021 ;653:103-120.
Gao S, Yao X, Yan N. Structure of human Ca2.2 channel blocked by the painkiller ziconotide. Nature. 2021 ;596(7870):143-147.
Li Z, Jin X, Wu T, Zhao X, Wang W, Lei J, et al. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021 ;118(11).
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, et al. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 ;371(6533).
2020
Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 ;117(31):18497-18503.
Gao S, Valinsky WC, On NCam, Houlihan PR, Qu Q, Liu L, et al. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020 ;117(25):14187-14193.
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, et al. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 ;581(7808):333-338.
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, et al. Structural basis of ion transport and inhibition in ferroportin. Nat Commun. 2020 ;11(1):5686.
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, et al. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 ;581(7808):329-332.
2019
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, et al. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019 ;576(7787):492-497.
Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 ;10(1):2320.
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, et al. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature. 2019 ;572(7769):347-351.
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, et al. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A. 2019 ;116(51):25575-25582.
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, et al. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019 ;177(6):1495-1506.e12.
Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, et al. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019 ;363(6433):1309-1313.
Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 ;363(6433):1303-1308.
Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, et al. Synaptic vesicle fusion: today and beyond. Nat Struct Mol Biol. 2019 ;26(8):663-668.
2018
Hogue IB, Jean J, Esteves AD, Tanneti NS, Scherer J, Enquist LW. Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26. J Virol. 2018 ;92(1).
Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, et al. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 ;47(2):248-256.e4.
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, et al. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018 ;362(6412).
Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, et al. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 ;361(6402).