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2020
Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 ;117(31):18497-18503.
Gao S, Valinsky WC, On NCam, Houlihan PR, Qu Q, Liu L, et al. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020 ;117(25):14187-14193.
Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, et al. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 ;581(7808):333-338.
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, et al. Structural basis of ion transport and inhibition in ferroportin. Nat Commun. 2020 ;11(1):5686.
Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, et al. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 ;581(7808):329-332.
2019
Zhao Y, Huang G, Wu Q, Wu K, Li R, Lei J, et al. Cryo-EM structures of apo and antagonist-bound human Ca3.1. Nature. 2019 ;576(7787):492-497.
Qian H, Cao P, Hu M, Gao S, Yan N, Gong X. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 ;10(1):2320.
Gong D, Chi X, Wei J, Zhou G, Huang G, Zhang L, et al. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature. 2019 ;572(7769):347-351.
Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, et al. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A. 2019 ;116(51):25575-25582.
Zhao Y, Huang G, Wu J, Wu Q, Gao S, Yan Z, et al. Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca Channel. Cell. 2019 ;177(6):1495-1506.e12.
Pan X, Li Z, Huang X, Huang G, Gao S, Shen H, et al. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019 ;363(6433):1309-1313.
Shen H, Liu D, Wu K, Lei J, Yan N. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 ;363(6433):1303-1308.
Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, et al. Synaptic vesicle fusion: today and beyond. Nat Struct Mol Biol. 2019 ;26(8):663-668.
2018
Hogue IB, Jean J, Esteves AD, Tanneti NS, Scherer J, Enquist LW. Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26. J Virol. 2018 ;92(1).
Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, et al. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 ;47(2):248-256.e4.
Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, et al. Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science. 2018 ;362(6412).
Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, et al. Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science. 2018 ;361(6402).
Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, et al. Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science. 2018 ;362(6412).
2017
Rosenzweig ESFreeman, Xu B, Cuellar LKuhn, Martinez-Sanchez A, Schaffer M, Strauss M, et al. The Eukaryotic CO-Concentrating Organelle Is Liquid-like and Exhibits Dynamic Reorganization. Cell. 2017 ;171(1):148-162.e19.
Lynch EM, Hicks DR, Shepherd M, Endrizzi JA, Maker A, Hansen JM, et al. Human CTP synthase filament structure reveals the active enzyme conformation. Nat Struct Mol Biol. 2017 ;24(6):507-514.
Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N. Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science. 2017 ;355(6328).
Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017 ;169(7):1228-1239.e10.
Yan Z, Zhou Q, Wang L, Wu J, Zhao Y, Huang G, et al. Structure of the Na1.4-β1 Complex from Electric Eel. Cell. 2017 ;170(3):470-482.e11.
2016
Bai X-C, Yan Z, Wu J, Li Z, Yan N. The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. 2016 ;26(9):995-1006.
Gong X, Qian H, Shao W, Li J, Wu J, Liu J-J, et al. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016 ;26(11):1197-1211.