Publications
A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis. Cell. 2017 ;168(1-2):172-185.e15.
. The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal. PLoS Biol. 2019 ;17(11):e3000429.
. Bacterial small-molecule signaling pathways. Science. 2006 ;311(5764):1113-6.
. A strategy for antagonizing quorum sensing. Mol Cell. 2011 ;42(2):199-209.
. Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation. J Bacteriol. 2009 ;191(1):169-77.
. Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae. Proc Natl Acad Sci U S A. 2007 ;104(27):11145-9.
. A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa. Mol Microbiol. 2016 ;101(4):590-605.
. Evidence for a signaling system in Helicobacter pylori: detection of a luxS-encoded autoinducer. J Bacteriol. 2000 ;182(13):3638-43.
. Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing. J Bacteriol. 2018 ;200(14).
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Discovery of as a global regulator of secondary metabolism and virulence in E264. Proc Natl Acad Sci U S A. 2017 ;114(14):E2920-E2928.
. Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell. 2002 ;110(3):303-14.
. Quorum sensing in bacteria. Annu Rev Microbiol. 2001 ;55:165-99.
. Both clinical and environmental Caulobacter species are virulent in the Galleria mellonella infection model. PLoS One. 2020 ;15(3):e0230006.
. The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017 ;13(7):e1006504.
. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 ;17(12):e3000579.
. Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios. PLoS Pathog. 2012 ;8(6):e1002767.
. A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A. 2013 ;110(44):17981-6.
. Flavonoids Suppress Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017 ;292(10):4064-4076.
. A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision. Cell. 2019 ;176(1-2):268-280.e13.
. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence. Proc Natl Acad Sci U S A. 2015 ;112(34):10679-84.
. Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chem Biol. 2016 ;23(2):214-224.
. Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chem Biol. 2017 ;24(1):76-86.
. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019 ;26(4):548-558.e4.
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