Publications
Quantitative flux analysis in mammals. Nat Metab. 2021 ;3(7):896-908.
. Proteomics and integrative omic approaches for understanding host-pathogen interactions and infectious diseases. Mol Syst Biol. 2017 ;13(3):922.
. Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods. 2021 ;18(11):1377-1385.
. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem Biol. 2021 ;16(12):2825-2833.
. Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022 ;665:305-323.
. Novel Pyrrolo[3,2-]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy. Mol Cancer Ther. 2019 ;18(10):1787-1799.
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Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. 2018 ;471:22-32.
. A reference tissue atlas for the human kidney. Sci Adv. 2022 ;8(23):eabn4965.
. Metabolomics and Isotope Tracing. Cell. 2018 ;173(4):822-837.
. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017 ;101(4):489-502.
. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022 ;4(1):141-152.
. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Mol Cancer Res. 2020 ;18(4):599-611.
. Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. Annu Rev Biochem. 2017 ;86:277-304.
. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Mol Cell. 2016 ;63(5):811-26.
. Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science. 2020 ;370(6514):364-368.
. Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis. ACS Chem Biol. 2016 ;11(8):2124-30.
. Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017 ;23(18):5639-5647.
. Metabolite Spectral Accuracy on Orbitraps. Anal Chem. 2017 ;89(11):5940-5948.
. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chem Biol. 2016 ;11(9):2420-7.
. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019 ;85(8).
. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink. Proc Natl Acad Sci U S A. 2016 ;113(6):1630-5.
. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019 ;15(2):161-168.
. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020 ;15(10):2766-2774.
. Traditional and novel tools to probe the mitochondrial metabolism in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2017 ;9(2).
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