Publications
Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019 ;20(1):50-63.
. Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering. Proc Natl Acad Sci U S A. 2019 ;116(48):24031-24040.
. Total Synthesis and Stereochemical Assignment of Streptide. J Am Chem Soc. 2019 ;141(43):17361-17369.
. Mechanistic Investigations of Lysine-Tryptophan Cross-Link Formation Catalyzed by Streptococcal Radical S-Adenosylmethionine Enzymes. Biochemistry. 2018 ;57(4):461-468.
. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018 ;27(5):1067-1080.e5.
. induces gut intraepithelial CD4CD8αα T cells. Science. 2017 ;357(6353):806-810.
. Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci. ACS Chem Biol. 2017 ;12(4):922-927.
. Structural basis for the binding of tryptophan-based motifs by δ-COP. Proc Natl Acad Sci U S A. 2015 ;112(46):14242-7.
. Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink. Nat Chem. 2015 ;7(5):431-437.
. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe. 2014 ;16(4):495-503.
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