Publications
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Filters: Keyword is Gene Expression Regulation, Neoplastic [Clear All Filters]
Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis. Cancer Cell. 2015 ;28(5):554-556.
. Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell. 2019 ;35(1):64-80.e7.
. Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Res. 2021 ;81(4):1014-1025.
. TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis. Nat Cell Biol. 2021 ;23(3):257-267.
. . Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. Genes Dev. 2020 ;34(23-24):1577-1598.
. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021 ;371(6532).
. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022 ;139(4):538-553.
. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019 ;10(1):2146.
. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol. 2017 ;19(6):711-723.
. Mouse genomic screen reveals novel host regulator of metastasis. Genome Biol. 2017 ;18(1):31.
. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021 ;3(11):1512-1520.
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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 ;114(43):11404-11409.
. HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement. Proc Natl Acad Sci U S A. 2020 ;117(50):31891-31901.
. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016 ;352(6287):844-9.
. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021 ;12(1):432.
. Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2. Genes Dev. 2020 ;34(19-20):1310-1315.
. Context-dependent EMT programs in cancer metastasis. J Exp Med. 2019 ;216(5):1016-1026.
. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 ;33(3-4):166-179.
. A biomimetic 3D model of hypoxia-driven cancer progression. Sci Rep. 2019 ;9(1):12263.
. ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes Dev. 2020 ;34(19-20):1359-1372.
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