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2022
Klibaite U, Kislin M, Verpeut JL, Bergeler S, Sun X, Shaevitz JW, et al. Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models. Mol Autism. 2022 ;13(1):12.
Shen M, Smith HA, Wei Y, Jiang Y-Z, Zhao S, Wang N, et al. Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat Cancer. 2022 ;3(1):60-74.
Zhao A, Bodine SP, Xie Q, Wang B, Ram G, Novick RP, et al. Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis. Proc Natl Acad Sci U S A. 2022 ;119(33):e2202661119.
Shen M, Wei Y, Kim H, Wan L, Jiang Y-Z, Hang X, et al. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022 ;3(1):43-59.
Wu X, Yan R, Cao P, Qian H, Yan N. Structural advances in sterol-sensing domain-containing proteins. Trends Biochem Sci. 2022 ;47(4):289-300.
Chen H, Zhan M, Liu J, Liu Z, Shen M, Yang F, et al. Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction. J Med Chem. 2022 ;65(18):12188-12199.
Buksh BF, Knutson SD, Oakley JV, Bissonnette NB, Oblinsky DG, Schwoerer MP, et al. μMap-Red: Proximity Labeling by Red Light Photocatalysis. J Am Chem Soc. 2022 ;144(14):6154-6162.
2021
Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias JW, et al. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021 ;12(1):432.
Landajuela A, Braun M, Rodrigues CDA, Martínez-Calvo A, Doan T, Horenkamp F, et al.. FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. PLoS Biol. 2021 ;19(6):e3001314.
Basta LP, Hill-Oliva M, Paramore SV, Sharan R, Goh A, Biswas A, et al. New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo. Development. 2021 ;148(18).
Dine E, Reed EH, Toettcher JE. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021 ;35(12):109280.
Yan R, Cao P, Song W, Li Y, Wang T, Qian H, et al. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021 ;35(13):109299.
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, et al. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 ;371(6533).
Shen M, Xie S, Rowicki M, Michel S, Wei Y, Hang X, et al. Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Res. 2021 ;81(4):1014-1025.
2020
Kaletsky R, Moore RS, Vrla GD, Parsons LR, Gitai Z, Murphy CT. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. 2020 ;586(7829):445-451.
Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 ;117(31):18497-18503.
Grimm J, Shi H, Wang W, Mitchell AM, Wingreen NS, Huang KCasey, et al. The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in . Proc Natl Acad Sci U S A. 2020 ;117(43):26907-26914.
Guest RL, Guerra DSamé, Wissler M, Grimm J, Silhavy TJ. YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide. mBio. 2020 ;11(2).
2019
Bialistoky T, Manry D, Smith P, Ng C, Kim Y, Zamir S, et al. Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in . Development. 2019 ;146(10).
Brose N, Brunger A, Cafiso D, Chapman ER, Diao J, Hughson FM, et al. Synaptic vesicle fusion: today and beyond. Nat Struct Mol Biol. 2019 ;26(8):663-668.
2018
Mitchell AM, Srikumar T, Silhavy TJ. Cyclic Enterobacterial Common Antigen Maintains the Outer Membrane Permeability Barrier of Escherichia coli in a Manner Controlled by YhdP. mBio. 2018 ;9(4).
Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, et al. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 ;47(2):248-256.e4.
Konovalova A, Grabowicz M, Balibar CJ, Malinverni JC, Painter RE, Riley D, et al. Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins. Proc Natl Acad Sci U S A. 2018 ;115(28):E6614-E6621.
Dine E, Gil AA, Uribe G, Brangwynne CP, Toettcher JE. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst. 2018 ;6(6):655-663.e5.
Ding Q, Gaska JM, Douam F, Wei L, Kim D, Balev M, et al. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018 ;115(27):E6310-E6318.