Publications
Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models. Mol Autism. 2022 ;13(1):12.
. Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat Cancer. 2022 ;3(1):60-74.
. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022 ;3(1):43-59.
. Structural advances in sterol-sensing domain-containing proteins. Trends Biochem Sci. 2022 ;47(4):289-300.
. μMap-Red: Proximity Labeling by Red Light Photocatalysis. J Am Chem Soc. 2022 ;144(14):6154-6162.
. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021 ;12(1):432.
. FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. PLoS Biol. 2021 ;19(6):e3001314.
. New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo. Development. 2021 ;148(18).
. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021 ;35(12):109280.
. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021 ;35(13):109299.
. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021 ;371(6533).
. Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Res. 2021 ;81(4):1014-1025.
. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. 2020 ;586(7829):445-451.
. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020 ;117(31):18497-18503.
. The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in . Proc Natl Acad Sci U S A. 2020 ;117(43):26907-26914.
. . Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in . Development. 2019 ;146(10).
. Synaptic vesicle fusion: today and beyond. Nat Struct Mol Biol. 2019 ;26(8):663-668.
. Cyclic Enterobacterial Common Antigen Maintains the Outer Membrane Permeability Barrier of Escherichia coli in a Manner Controlled by YhdP. mBio. 2018 ;9(4).
. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 ;47(2):248-256.e4.
. Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins. Proc Natl Acad Sci U S A. 2018 ;115(28):E6614-E6621.
. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst. 2018 ;6(6):655-663.e5.
. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018 ;115(27):E6310-E6318.
. . .