Publications
Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation. Cell Rep. 2022 ;38(12):110543.
. Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk. Nat Genet. 2021 ;53(2):166-173.
. The Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in for Bidirectional Control of Gene Expression. ACS Synth Biol. 2021 ;10(8):2060-2075.
. Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress?. Cell Death Differ. 2021 ;28(4):1434-1436.
. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Nat Commun. 2020 ;11(1):4627.
. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019 ;14(3):378-389.
. Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers. mBio. 2019 ;10(2).
. Structural determinants driving homoserine lactone ligand selection in the LasR quorum-sensing receptor. Proc Natl Acad Sci U S A. 2019 ;116(1):245-254.
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Flavonoids Suppress Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017 ;292(10):4064-4076.
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Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices. Sci Rep. 2015 ;5:11458.
. Quorum sensing regulates the osmotic stress response in Vibrio harveyi. J Bacteriol. 2015 ;197(1):73-80.
. Stable Pseudohyphal Growth in Budding Yeast Induced by Synergism between Septin Defects and Altered MAP-kinase Signaling. PLoS Genet. 2015 ;11(12):e1005684.
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Individual and combined roles of the master regulators AphA and LuxR in control of the Vibrio harveyi quorum-sensing regulon. J Bacteriol. 2013 ;195(3):436-43.
. A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A. 2013 ;110(44):17981-6.
. Quorum-sensing non-coding small RNAs use unique pairing regions to differentially control mRNA targets. Mol Microbiol. 2012 ;83(3):599-611.
. AphA and LuxR/HapR reciprocally control quorum sensing in vibrios. Genes Dev. 2011 ;25(4):397-408.
. A strategy for antagonizing quorum sensing. Mol Cell. 2011 ;42(2):199-209.
. Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA. Appl Environ Microbiol. 2010 ;76(15):4996-5004.
. Measurement of the copy number of the master quorum-sensing regulator of a bacterial cell. Biophys J. 2010 ;98(9):2024-31.
. A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. Mol Cell. 2009 ;35(2):143-53.
. Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J Bacteriol. 2008 ;190(7):2527-36.
. A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi. Mol Microbiol. 2008 ;70(4):896-907.
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