Publications
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Author Title [ Year
Filters: Keyword is Single-Cell Analysis [Clear All Filters]
Genome organization controls transcriptional dynamics during development. Science. 2022 ;375(6580):566-570.
. Neuronal identities derived by misexpression of the POU IV sensory determinant in a protovertebrate. Proc Natl Acad Sci U S A. 2022 ;119(4).
. Spatially resolved isotope tracing reveals tissue metabolic activity. Nat Methods. 2022 ;19(2):223-230.
. Transcriptional coupling of distant regulatory genes in living embryos. Nature. 2022 ;605(7911):754-760.
. An analytical framework for interpretable and generalizable single-cell data analysis. Nat Methods. 2021 ;18(11):1317-1321.
. Attenuated activation of pulmonary immune cells in mRNA-1273-vaccinated hamsters after SARS-CoV-2 infection. J Clin Invest. 2021 ;131(20).
. Evaluating totipotency using criteria of increasing stringency. Nat Cell Biol. 2021 ;23(1):49-60.
. Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning. Nat Genet. 2021 ;53(4):487-499.
. Pseudomonas aeruginosa detachment from surfaces via a self-made small molecule. J Biol Chem. 2021 ;296:100279.
. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021 ;371(6532).
. Spatial transcriptional mapping of the human nephrogenic program. Dev Cell. 2021 ;56(16):2381-2398.e6.
. Uncovering cellular networks in branching morphogenesis using single-cell transcriptomics. Curr Top Dev Biol. 2021 ;143:239-280.
. Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy. Science. 2020 ;369(6499):71-77.
. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol. 2020 ;38(8):954-961.
. Molecular recording of mammalian embryogenesis. Nature. 2019 ;570(7759):77-82.
. Organoid single cell profiling identifies a transcriptional signature of glomerular disease. JCI Insight. 2019 ;4(1).
. Shared evolutionary origin of vertebrate neural crest and cranial placodes. Nature. 2018 ;560(7717):228-232.
. Parallel imaging of embryos for quantitative analysis of genetic perturbations of the Ras pathway. Dis Model Mech. 2017 ;10(7):923-929.
. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nat Commun. 2017 ;8:14781.
. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017 ;67(5):757-769.e5.
. Architectural transitions in Vibrio cholerae biofilms at single-cell resolution. Proc Natl Acad Sci U S A. 2016 ;113(14):E2066-72.
. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 ;167(7):1867-1882.e21.
. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 ;167(7):1853-1866.e17.
. Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging. Proc Natl Acad Sci U S A. 2016 ;113(36):E5337-43.
. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 ;155(6):1422-34.
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