Publications
CanE, an Iron/2-Oxoglutarate-Dependent Lasso Peptide Hydroxylase from . ACS Chem Biol. 2020 ;15(4):890-894.
. Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy. Science. 2020 ;369(6499):71-77.
. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020 ;16(9):e1008867.
. Discovery of PqsE Thioesterase Inhibitors for Using DNA-Encoded Small Molecule Library Screening. ACS Chem Biol. 2020 ;15(2):446-456.
. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na channels in nanodisc. Proc Natl Acad Sci U S A. 2020 ;117(25):14187-14193.
. Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling biofilm dispersal. Proc Natl Acad Sci U S A. 2020 ;117(51):32639-32647.
. Mechanism underlying autoinducer recognition in the DPO-VqmA quorum-sensing pathway. J Biol Chem. 2020 ;295(10):2916-2931.
. . Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019 ;141(27):10610-10615.
. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019 ;14(3):378-389.
. An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation. PLoS Pathog. 2019 ;15(6):e1007820.
. Envelope stress responses: balancing damage repair and toxicity. Nat Rev Microbiol. 2019 ;17(7):417-428.
. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019 ;26(4):548-558.e4.
. The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal. PLoS Biol. 2019 ;17(11):e3000429.
. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 ;17(12):e3000579.
. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019 ;141(2):990-997.
. Structural determinants driving homoserine lactone ligand selection in the LasR quorum-sensing receptor. Proc Natl Acad Sci U S A. 2019 ;116(1):245-254.
. Surface association sensitizes Pseudomonas aeruginosa to quorum sensing. Nat Commun. 2019 ;10(1):4118.
. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019 ;116(9):3752-3757.
. Albusnodin: an acetylated lasso peptide from Streptomyces albus. Chem Commun (Camb). 2018 ;54(11):1339-1342.
. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018 ;140(50):17674-17684.
. Field-deployable viral diagnostics using CRISPR-Cas13. Science. 2018 ;360(6387):444-448.
. A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus. Nat Microbiol. 2018 ;3(8):948-959.
. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018 ;606:439-460.
. Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing. J Bacteriol. 2018 ;200(14).
.