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2022
Wilke AC, Doebele C, Zindel A, Lee KSeok, Rieke SA, Ceribelli M, et al. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022 ;139(4):538-553.
2021
Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias JW, et al. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021 ;12(1):432.
Wu A, Zhi J, Tian T, Cihan A, Cevher MA, Liu Z, et al. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021 ;118(27).
Wei L, Ploss A. Hepatitis B virus cccDNA is formed through distinct repair processes of each strand. Nat Commun. 2021 ;12(1):1591.
Phan T, Nguyen VH, Buettner R, Morales C, Yang L, Wong P, et al. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int J Biol Sci. 2021 ;17(9):2240-2251.
Chitrakar A, Solorio-Kirpichyan K, Prangley E, Rath S, Du J, Korennykh A. Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L. Proc Natl Acad Sci U S A. 2021 ;118(46).
Nimgaonkar I, Archer NF, Becher I, Shahrad M, LeDesma RA, Mateus A, et al. Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res. 2021 ;185:104997.
Rabie EM, Zhang SX, Kourouklis AP, A Kilinc N, Simi AK, Radisky DC, et al. Matrix degradation and cell proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. Integr Biol (Camb). 2021 ;13(1):17-29.
Zhang Y, Lee DSW, Meir Y, Brangwynne CP, Wingreen NS. Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin. Phys Rev Lett. 2021 ;126(25):258102.
Ghergurovich JM, Xu X, Wang JZ, Yang L, Ryseck R-P, Wang L, et al. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021 ;3(11):1512-1520.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, et al. mTORC1 promotes cell growth via mA-dependent mRNA degradation. Mol Cell. 2021 ;81(10):2064-2075.e8.
Schild T, McReynolds MR, Shea C, Low V, Schaffer BE, Asara JM, et al. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021 ;35(11):109238.
Shimobayashi SF, Ronceray P, Sanders DW, Haataja MP, Brangwynne CP. Nucleation landscape of biomolecular condensates. Nature. 2021 ;599(7885):503-506.
Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, et al. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021 ;371(6532).
Esposito M, Fang C, Cook KC, Park N, Wei Y, Spadazzi C, et al. TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis. Nat Cell Biol. 2021 ;23(3):257-267.
2020
Fan H, Wang X, Li W, Shen M, Wei Y, Zheng H, et al. ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAP. Genes Dev. 2020 ;34(19-20):1359-1372.
Sanders DW, Kedersha N, Lee DSW, Strom AR, Drake V, Riback JA, et al. Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. Cell. 2020 ;181(2):306-324.e28.
Ghergurovich JM, Esposito M, Chen Z, Wang JZ, Bhatt V, Lan T, et al. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020 ;80(18):3820-3829.
Nogalski MT, Shenk T. HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement. Proc Natl Acad Sci U S A. 2020 ;117(50):31891-31901.
Hermans D, Gautam S, García-Cañaveras JC, Gromer D, Mitra S, Spolski R, et al.. Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 T cell stemness and antitumor immunity. Proc Natl Acad Sci U S A. 2020 ;117(11):6047-6055.
McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, et al. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, et al.. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020 ;183(7):1848-1866.e26.
Anlas AA, Nelson CM. Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase. Cancer Res. 2020 ;80(19):4103-4113.
2019
Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin S-C, et al. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019 ;21(5):627-639.
Zhang H, Brown RL, Wei Y, Zhao P, Liu S, Liu X, et al. CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 ;33(3-4):166-179.