Publications
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020 ;2(11):1284-1304.
. Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing. Nat Biotechnol. 2020 ;38(8):954-961.
. Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold. Nat Commun. 2020 ;11(1):4045.
. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell. 2020 ;181(7):1518-1532.e14.
. Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid. Mol Cell. 2020 ;80(6):1078-1091.e6.
. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. 2020 ;577(7788):121-126.
. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020 ;27(9):836-845.
. Optogenetic control of protein binding using light-switchable nanobodies. Nat Commun. 2020 ;11(1):4044.
. . Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. mBio. 2019 ;10(4).
. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat Commun. 2019 ;10(1):2320.
. Molecular basis for pore blockade of human Na channel Na1.2 by the μ-conotoxin KIIIA. Science. 2019 ;363(6433):1309-1313.
. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019 ;10(1):2146.
. Programmable Inhibition and Detection of RNA Viruses Using Cas13. Mol Cell. 2019 ;76(5):826-837.e11.
. Proximity Induced Splicing Utilizing Caged Split Inteins. J Am Chem Soc. 2019 ;141(35):13708-13712.
. Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching. Biophys J. 2019 ;117(7):1285-1300.
. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019 ;179(6):1342-1356.e23.
. Structures of human Na1.7 channel in complex with auxiliary subunits and animal toxins. Science. 2019 ;363(6433):1303-1308.
. Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription. Elife. 2018 ;7.
. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018 ;7(1):49-62.e8.
. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018 ;9(1):1394.
. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 ;47(2):248-256.e4.
. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell. 2018 ;175(6):1481-1491.e13.
. Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds. Cell. 2018 ;175(6):1467-1480.e13.
. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. 2018 ;554(7690):128-132.
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