Publications
Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat Genet. 2017 ;49(3):465-469.
. In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proc Natl Acad Sci U S A. 2017 ;114(3):510-515.
. Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Methods Mol Biol. 2017 ;1636:3-20.
. Parallel imaging of embryos for quantitative analysis of genetic perturbations of the Ras pathway. Dis Model Mech. 2017 ;10(7):923-929.
. The Spatiotemporal Limits of Developmental Erk Signaling. Dev Cell. 2017 ;40(2):185-192.
. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017 ;67(5):757-769.e5.
. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016 ;30(15):1704-17.
. RASopathies: unraveling mechanisms with animal models. Dis Model Mech. 2015 ;8(8):769-82.
. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 ;155(6):1422-34.
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