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Author Title [ Year(Asc)]
Filters: Keyword is Structure-Activity Relationship  [Clear All Filters]
2019
Chitrakar A, Rath S, Donovan J, Demarest K, Li Y, Sridhar RRao, et al. Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L. Proc Natl Acad Sci U S A. 2019 ;116(6):2103-2111.
2016
Bai X-C, Yan Z, Wu J, Li Z, Yan N. The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. 2016 ;26(9):995-1006.
2015
Miller LC, O'Loughlin CT, Zhang Z, Siryaporn A, Silpe JE, Bassler BL, et al. Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa. J Med Chem. 2015 ;58(3):1298-306.
Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, et al. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proc Natl Acad Sci U S A. 2015 ;112(33):10365-70.
Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, et al. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015 ;526(7573):391-6.
2014
Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, et al. Crystal structure of the human glucose transporter GLUT1. Nature. 2014 ;510(7503):121-5.
McKoy AF, Chen J, Schüpbach T, Hecht MH. Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42. Chem Biol Drug Des. 2014 ;84(5):505-12.
2012
Ng W-L, Perez L, Cong J, Semmelhack MF, Bassler BL. Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios. PLoS Pathog. 2012 ;8(6):e1002767.
Sun L, Zeng X, Yan C, Sun X, Gong X, Rao Y, et al. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature. 2012 ;490(7420):361-6.
Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, et al. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. 2012 ;486(7401):130-4.
2011
Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, et al. A strategy for antagonizing quorum sensing. Mol Cell. 2011 ;42(2):199-209.
Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, et al. Structure and mechanism of the uracil transporter UraA. Nature. 2011 ;472(7342):243-6.
2010
Hao Q, Yin P, Yan C, Yuan X, Li W, Zhang Z, et al. Functional mechanism of the abscisic acid agonist pyrabactin. J Biol Chem. 2010 ;285(37):28946-52.
2009
Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, et al. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature. 2009 ;462(7272):467-72.
2006
Cosgrove MS, Bever K, Avalos JL, Muhammad S, Zhang X, Wolberger C. The structural basis of sirtuin substrate affinity. Biochemistry. 2006 ;45(24):7511-21.