Publications
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Filters: Keyword is Structure-Activity Relationship [Clear All Filters]
Comparative structural analysis of human Na1.1 and Na1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 ;118(11).
. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021 ;118(3).
. Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021 ;118(11).
. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J Nat Prod. 2020 ;83(3):738-743.
. Discovery of PqsE Thioesterase Inhibitors for Using DNA-Encoded Small Molecule Library Screening. ACS Chem Biol. 2020 ;15(2):446-456.
. Mechanism underlying autoinducer recognition in the DPO-VqmA quorum-sensing pathway. J Biol Chem. 2020 ;295(10):2916-2931.
. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020 ;117(48):30465-30475.
. Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2. Cell. 2020 ;182(1):98-111.e18.
. Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature. 2020 ;581(7808):329-332.
. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019 ;14(3):378-389.
. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol. 2019 ;17(6):e3000316.
. Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L. Proc Natl Acad Sci U S A. 2019 ;116(6):2103-2111.
. Structural determinants driving homoserine lactone ligand selection in the LasR quorum-sensing receptor. Proc Natl Acad Sci U S A. 2019 ;116(1):245-254.
. Flavonoids Suppress Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017 ;292(10):4064-4076.
. Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles. Proc Natl Acad Sci U S A. 2017 ;114(5):1147-1152.
. Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE. PLoS Comput Biol. 2017 ;13(6):e1005603.
. Structure-based assessment of disease-related mutations in human voltage-gated sodium channels. Protein Cell. 2017 ;8(6):401-438.
. The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell Res. 2016 ;26(9):995-1006.
. Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa. J Med Chem. 2015 ;58(3):1298-306.
. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proc Natl Acad Sci U S A. 2015 ;112(33):10365-70.
. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015 ;526(7573):391-6.
. Crystal structure of the human glucose transporter GLUT1. Nature. 2014 ;510(7503):121-5.
. Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42. Chem Biol Drug Des. 2014 ;84(5):505-12.
. Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios. PLoS Pathog. 2012 ;8(6):e1002767.
. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature. 2012 ;490(7420):361-6.
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