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2021
Koch MD, Fei C, Wingreen NS, Shaevitz JW, Gitai Z. Competitive binding of independent extension and retraction motors explains the quantitative dynamics of type IV pili. Proc Natl Acad Sci U S A. 2021 ;118(8).
Taylor IR, Paczkowski JE, Jeffrey PD, Henke BR, Smith CD, Bassler BL. Inhibitor Mimetic Mutations in the PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. ACS Chem Biol. 2021 ;16(4):740-752.
Scheffler RJ, Sugimoto Y, Bratton BP, Ellison CK, Koch MD, Donia MS, et al. Pseudomonas aeruginosa detachment from surfaces via a self-made small molecule. J Biol Chem. 2021 ;296:100279.
Sivaloganathan DM, Brynildsen MP. Pseudomonas aeruginosa prioritizes detoxification of hydrogen peroxide over nitric oxide. BMC Res Notes. 2021 ;14(1):120.
2020
Kaletsky R, Moore RS, Vrla GD, Parsons LR, Gitai Z, Murphy CT. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. 2020 ;586(7829):445-451.
Vrla GD, Esposito M, Zhang C, Kang Y, Seyedsayamdost MR, Gitai Z. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020 ;16(9):e1008867.
Valastyan JS, Tota MR, Taylor IR, Stergioula V, Hone GAB, Smith CD, et al. Discovery of PqsE Thioesterase Inhibitors for Using DNA-Encoded Small Molecule Library Screening. ACS Chem Biol. 2020 ;15(2):446-456.
Martin JK, Sheehan JP, Bratton BP, Moore GM, Mateus A, Li SHsin-Jung, et al. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell. 2020 ;181(7):1518-1532.e14.
2019
Paczkowski JE, McCready AR, Cong J-P, Li Z, Jeffrey PD, Smith CD, et al. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019 ;14(3):378-389.
McCready AR, Paczkowski JE, Cong J-P, Bassler BL. An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation. PLoS Pathog. 2019 ;15(6):e1007820.
Okada BK, Li A, Seyedsayamdost MR. Identification of the Hypertension Drug Guanfacine as an Antivirulence Agent in Pseudomonas aeruginosa. Chembiochem. 2019 ;20(15):2005-2011.
Sanfilippo JE, Lorestani A, Koch MD, Bratton BP, Siryaporn A, Stone HA, et al. Microfluidic-based transcriptomics reveal force-independent bacterial rheosensing. Nat Microbiol. 2019 ;4(8):1274-1281.
Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler BL. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 ;17(12):e3000579.
Moore RS, Kaletsky R, Murphy CT. Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance. Cell. 2019 ;177(7):1827-1841.e12.
McCready AR, Paczkowski JE, Henke BR, Bassler BL. Structural determinants driving homoserine lactone ligand selection in the LasR quorum-sensing receptor. Proc Natl Acad Sci U S A. 2019 ;116(1):245-254.
Chuang SK, Vrla GD, Fröhlich KS, Gitai Z. Surface association sensitizes Pseudomonas aeruginosa to quorum sensing. Nat Commun. 2019 ;10(1):4118.
2018
Kannan A, Yang Z, Kim MKevin, Stone HA, Siryaporn A. Dynamic switching enables efficient bacterial colonization in flow. Proc Natl Acad Sci U S A. 2018 ;115(21):5438-5443.
Trivedi RR, Crooks JA, Auer GK, Pendry J, Foik IP, Siryaporn A, et al. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018 ;9(5).
Mukherjee S, Moustafa DA, Stergioula V, Smith CD, Goldberg JB, Bassler BL. The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in . Proc Natl Acad Sci U S A. 2018 ;115(40):E9411-E9418.
2017
Paczkowski JE, Mukherjee S, McCready AR, Cong J-P, Aquino CJ, Kim H, et al. Flavonoids Suppress Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017 ;292(10):4064-4076.
Nadell CD, Ricaurte D, Yan J, Drescher K, Bassler BL. Flow environment and matrix structure interact to determine spatial competition in biofilms. Elife. 2017 ;6.
Robinson JL, Jaslove JM, Murawski AM, Fazen CH, Brynildsen MP. An integrated network analysis reveals that nitric oxide reductase prevents metabolic cycling of nitric oxide by Pseudomonas aeruginosa. Metab Eng. 2017 ;41:67-81.
Høyland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, et al.. Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proc Natl Acad Sci U S A. 2017 ;114(1):131-135.
Mukherjee S, Moustafa D, Smith CD, Goldberg JB, Bassler BL. The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017 ;13(7):e1006504.