Publications
Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020 ;2(7):566-571.
. Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol. 2020 ;18(8):e3000757.
. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020 ;16(7):731-739.
. A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1. PLoS One. 2020 ;15(5):e0233779.
. Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nat Chem Biol. 2019 ;15(10):1001-1008.
. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Res. 2019 ;79(13):3155-3162.
. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018 ;7(1):49-62.e8.
. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018 ;27(2):351-361.e3.
. Enhancing CD8 T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017 ;32(3):377-391.e9.
. A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters. J Mol Biol. 2017 ;429(17):2710-2725.
. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 ;551(7678):115-118.
. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circ Res. 2017 ;121(12):1370-1378.
. The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. 2016 ;65(9):2711-23.
. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metab. 2016 ;23(6):1154-1166.
. Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP. Sci Rep. 2016 ;6:24834.
. GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters. Protein Sci. 2016 ;25(3):546-58.
. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016 ;24(2):269-82.
. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Mol Cell. 2016 ;63(5):811-26.
. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016 ;24(6):863-874.
. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015 ;526(7573):391-6.
. RNA Futile Cycling in Model Persisters Derived from MazF Accumulation. mBio. 2015 ;6(6):e01588-15.
. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell. 2014 ;25(16):2342-50.
. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature. 2012 ;490(7420):361-6.
. Regulation of autoinducer production in Salmonella typhimurium. Mol Microbiol. 1999 ;31(2):585-95.
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