Publications
Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol. 2021 ;10(5):1143-1154.
. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021 ;35(12):109280.
. Temperature-Induced uncoupling of cell cycle regulators. Dev Biol. 2021 ;470:147-153.
. Functional divergence caused by mutations in an energetic hotspot in ERK2. Proc Natl Acad Sci U S A. 2019 ;116(31):15514-15523.
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How activating mutations affect MEK1 regulation and function. J Biol Chem. 2017 ;292(46):18814-18820.
. Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene. 2017 ;36(27):3797-3806.
. The Spatiotemporal Limits of Developmental Erk Signaling. Dev Cell. 2017 ;40(2):185-192.
. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017 ;67(5):757-769.e5.
. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nat Chem Biol. 2016 ;12(3):188-93.
. Dynamics of Inductive ERK Signaling in the Drosophila Embryo. Curr Biol. 2015 ;25(13):1784-90.
. A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline. Biophys J. 2015 ;109(11):2436-45.
. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. Proc Natl Acad Sci U S A. 2013 ;110(5):1652-7.
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Regulation of quorum sensing in Vibrio harveyi by LuxO and sigma-54. Mol Microbiol. 2000 ;36(4):940-54.
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