Publications
] . Enhanced antibiotic resistance development from fluoroquinolone persisters after a single exposure to antibiotic. Nat Commun. 2019 ;10(1):1177.
. Programmable Inhibition and Detection of RNA Viruses Using Cas13. Mol Cell. 2019 ;76(5):826-837.e11.
. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018 ;140(50):17674-17684.
. The effect of antibiotics on protein diffusion in the Escherichia coli cytoplasmic membrane. PLoS One. 2017 ;12(10):e0185810.
. Long-range proton-coupled electron transfer in theclass Ia ribonucleotide reductase. Essays Biochem. 2017 ;61(2):281-292.
. The Activity of Escherichia coli Chaperone SurA Is Regulated by Conformational Changes Involving a Parvulin Domain. J Bacteriol. 2016 ;198(6):921-9.
. Analyzing Persister Physiology with Fluorescence-Activated Cell Sorting. Methods Mol Biol. 2016 ;1333:83-100.
. Classic Spotlight: a Very Pleiotropic Mutant. J Bacteriol. 2016 ;198(3):371.
. The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane. MBio. 2016 ;7(2):e00312-16.
. A de novo protein confers copper resistance in Escherichia coli. Protein Sci. 2016 ;25(7):1249-59.
. De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic. J Mol Biol. 2016 ;428(2 Pt A):399-411.
. Discovery and dissection of metabolic oscillations in the microaerobic nitric oxide response network of Escherichia coli. Proc Natl Acad Sci U S A. 2016 ;113(12):E1757-66.
. Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway. Proc Natl Acad Sci U S A. 2016 ;113(11):E1565-74.
. Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP. Biochemistry. 2016 ;55(39):5554-5565.
. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink. Proc Natl Acad Sci U S A. 2016 ;113(6):1630-5.
. Persister formation in Escherichia coli can be inhibited by treatment with nitric oxide. Free Radic Biol Med. 2016 ;93:145-54.
. A protein constructed de novo enables cell growth by altering gene regulation. Proc Natl Acad Sci U S A. 2016 ;113(9):2400-5.
. Comprehensive analysis reveals how single nucleotides contribute to noncoding RNA function in bacterial quorum sensing. Proc Natl Acad Sci U S A. 2015 ;112(44):E6038-47.
. Divergent evolution of a bifunctional de novo protein. Protein Sci. 2015 ;24(2):246-52.
. An ensemble-guided approach identifies ClpP as a major regulator of transcript levels in nitric oxide-stressed Escherichia coli. Metab Eng. 2015 ;31:22-34.
. Established Microbial Colonies Can Survive Type VI Secretion Assault. PLoS Comput Biol. 2015 ;11(10):e1004520.
. Inhibition of stationary phase respiration impairs persister formation in E. coli. Nat Commun. 2015 ;6:7983.
. A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli. PLoS Comput Biol. 2015 ;11(11):e1004562.
. The mechanical world of bacteria. Cell. 2015 ;161(5):988-997.
. Persister Heterogeneity Arising from a Single Metabolic Stress. Curr Biol. 2015 ;25(16):2090-8.