Publications
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020 ;2(11):1284-1304.
. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020 ;369(6502):397-403.
. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020 ;16(9):e1008867.
. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020 ;579(7800):586-591.
. Efficient Generation of Large-Fragment Knock-In Mouse Models Using 2-Cell (2C)-Homologous Recombination (HR)-CRISPR. Curr Protoc Mouse Biol. 2020 ;10(1):e67.
. Generation of Large Fragment Knock-In Mouse Models by Microinjecting into 2-Cell Stage Embryos. Methods Mol Biol. 2020 ;2066:89-100.
. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nat Genet. 2020 ;52(8):769-777.
. Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis. Cancer Res. 2020 ;80(18):3820-3829.
. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020 ;369(6509):1388-1394.
. Identification of Plasmodium falciparum proteoforms from liver stage models. Malar J. 2020 ;19(1):10.
. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature. 2020 ;577(7788):121-126.
. Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 T cell stemness and antitumor immunity. Proc Natl Acad Sci U S A. 2020 ;117(11):6047-6055.
. Mechanics of a multilayer epithelium instruct tumour architecture and function. Nature. 2020 ;585(7825):433-439.
. A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. Cell. 2020 ;180(4):717-728.e19.
. Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses. J Vis Exp. 2020 ;(160).
. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol. 2020 ;22(10):1187-1196.
. Optogenetic control of protein binding using light-switchable nanobodies. Nat Commun. 2020 ;11(1):4044.
. RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters. PLoS Pathog. 2020 ;16(2):e1008269.
. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. 2020 ;107(5):821-835.e12.
. The small intestine shields the liver from fructose-induced steatosis. Nat Metab. 2020 ;2(7):586-593.
. Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma. Proc Natl Acad Sci U S A. 2019 ;116(9):3883-3892.
. Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling. PLoS Pathog. 2019 ;15(11):e1008087.
. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019 ;21(5):627-639.
. . CD44 splice isoform switching determines breast cancer stem cell state. Genes Dev. 2019 ;33(3-4):166-179.
.