Yellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe.

TitleYellow Fever Virus: Knowledge Gaps Impeding the Fight Against an Old Foe.
Publication TypeJournal Article
Year of Publication2018
AuthorsDouam, F, Ploss, A
JournalTrends Microbiol
Volume26
Issue11
Pagination913-928
Date Published2018 11
ISSN1878-4380
KeywordsAfrica, Animals, Disease Models, Animal, Disease Outbreaks, History, 18th Century, History, 19th Century, History, 20th Century, History, 21st Century, Host-Pathogen Interactions, Humans, Mosquito Control, RNA, Viral, South America, Vaccination, Vaccines, Attenuated, Yellow Fever, Yellow Fever Vaccine, Yellow fever virus
Abstract

<p>Yellow fever (YF) was one of the most dangerous infectious diseases of the 18th and 19th centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is yellow fever virus (YFV), and its live-attenuated form, YFV-17D, remains one of the most potent vaccines ever developed. During the first half of the 20th century, vaccination combined with mosquito control eradicated YFV transmission in urban areas. However, the recent 2016-2018 outbreaks in areas with historically low or no YFV activity have raised serious concerns for an estimated 400-500 million unvaccinated people who now live in at-risk areas. Once a forgotten disease, we highlight here that YF still represents a very real threat to human health and economies. As many gaps remain in our understanding of how YFV interacts with the human host and causes disease, there is an urgent need to address these knowledge gaps and propel YFV research forward.</p>

DOI10.1016/j.tim.2018.05.012
Alternate JournalTrends Microbiol.
PubMed ID29933925
PubMed Central IDPMC6340642
Grant ListR21 AI117213 / AI / NIAID NIH HHS / United States
R03 DK117252 / DK / NIDDK NIH HHS / United States
R21 AI106000 / AI / NIAID NIH HHS / United States
K08 DK101754 / DK / NIDDK NIH HHS / United States
R01 AI107301 / AI / NIAID NIH HHS / United States