| Title | Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Alečković, M, Kang, Y |
| Journal | Cancer Cell |
| Volume | 28 |
| Issue | 5 |
| Pagination | 554-556 |
| Date Published | 2015 Nov 09 |
| ISSN | 1878-3686 |
| Keywords | Animals, Brain Neoplasms, Exosomes, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Male, MicroRNAs, PTEN Phosphohydrolase, Tumor Microenvironment |
| Abstract | <p>Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis. </p> |
| DOI | 10.1016/j.ccell.2015.10.010 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 26555172 |
