Title | In vivo models of hepatitis B and C virus infection. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Winer, BY, Ding, Q, Gaska, JM, Ploss, A |
Journal | FEBS Lett |
Volume | 590 |
Issue | 13 |
Pagination | 1987-99 |
Date Published | 2016 Jul |
ISSN | 1873-3468 |
Keywords | Animals, Disease Models, Animal, Hepatitis B, Hepatitis C, Hepatitis Viruses, Host Specificity, Humans, Species Specificity |
Abstract | <p>Globally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses.</p> |
DOI | 10.1002/1873-3468.12157 |
Alternate Journal | FEBS Lett |
PubMed ID | 27009462 |
PubMed Central ID | PMC4945464 |
Grant List | R01 AI106005 / AI / NIAID NIH HHS / United States R01 AI079031 / AI / NIAID NIH HHS / United States R21 AI117213 / AI / NIAID NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States R56 AI106005 / AI / NIAID NIH HHS / United States R01 AI107301 / AI / NIAID NIH HHS / United States |