¡Viva la mitochondria!: harnessing yeast mitochondria for chemical production.

Title¡Viva la mitochondria!: harnessing yeast mitochondria for chemical production.
Publication TypeJournal Article
Year of Publication2020
AuthorsDuran, L, López, JMontaño, Avalos, JL
JournalFEMS Yeast Res
Volume20
Issue6
Date Published2020 Sep 01
ISSN1567-1364
Abstract

<p>The mitochondria, often referred to as the powerhouse of the cell, offer a unique physicochemical environment enriched with a distinct set of enzymes, metabolites and cofactors ready to be exploited for metabolic engineering. In this review, we discuss how the mitochondrion has been engineered in the traditional sense of metabolic engineering or completely bypassed for chemical production. We then describe the more recent approach of harnessing the mitochondria to compartmentalize engineered metabolic pathways, including for the production of alcohols, terpenoids, sterols, organic acids and other valuable products. We explain the different mechanisms by which mitochondrial compartmentalization benefits engineered metabolic pathways to boost chemical production. Finally, we discuss the key challenges that need to be overcome to expand the applicability of mitochondrial engineering and reach the full potential of this emerging field.</p>

DOI10.1093/femsyr/foaa037
Alternate JournalFEMS Yeast Res.
PubMed ID32592388