Virus-host protein interactions as footprints of human cytomegalovirus replication.

TitleVirus-host protein interactions as footprints of human cytomegalovirus replication.
Publication TypeJournal Article
Year of Publication2022
AuthorsTyl, MD, Betsinger, CN, Cristea, IM
JournalCurr Opin Virol
Volume52
Pagination135-147
Date Published2022 02
ISSN1879-6265
KeywordsCytomegalovirus, Cytomegalovirus Infections, Host Microbial Interactions, Host-Pathogen Interactions, Humans, Virus Replication
Abstract

<p>Human cytomegalovirus (HCMV) is a pervasive β-herpesvirus that causes lifelong infection. The lytic replication cycle of HCMV is characterized by global organelle remodeling and dynamic virus-host interactions, both of which are necessary for productive HCMV replication. With the advent of new technologies for investigating protein-protein and protein-nucleic acid interactions, numerous critical interfaces between HCMV and host cells have been identified. Here, we review temporal and spatial virus-host interactions that support different stages of the HCMV replication cycle. Understanding how HCMV interacts with host cells during entry, replication, and assembly, as well as how it interfaces with host cell metabolism and immune responses promises to illuminate processes that underlie the biology of infection and the resulting pathologies.</p>

DOI10.1016/j.coviro.2021.11.016
Alternate JournalCurr Opin Virol
PubMed ID34923282
PubMed Central IDPMC8844139
Grant ListF31 AI154796 / AI / NIAID NIH HHS / United States
R01 GM114141 / GM / NIGMS NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States