The use of humanized mice for studies of viral pathogenesis and immunity.

TitleThe use of humanized mice for studies of viral pathogenesis and immunity.
Publication TypeJournal Article
Year of Publication2018
AuthorsDouam, F, Ploss, A
JournalCurr Opin Virol
Volume29
Pagination62-71
Date Published2018 Mar 28
ISSN1879-6265
Abstract

Humanized mice, that is, animals engrafted with human tissues and/or expressing human genes, have been instrumental in improving our understanding of the pathogenesis and immunological processes that define some of the most challenging human-tropic viruses. In particular, mice engrafted with components of a human immune system (HIS) offer unprecedented opportunities for mechanistic studies of human immune responses to infection. Here, we provide a brief overview of the current panel of HIS mouse models available and cite recent examples of how such humanized animals have been used to study immune responses and pathogenesis elicited by human-tropic viruses. Finally, we will outline some of the challenges that lay ahead and strategies to improve and refine humanized mice with the goal of more accurately recapitulating human immune responses to viral infection.

DOI10.1016/j.coviro.2018.03.003
Alternate JournalCurr Opin Virol
PubMed ID29604551
Grant ListR01 AI079031 / AI / NIAID NIH HHS / United States
R01 AI107301 / AI / NIAID NIH HHS / United States