Twists and turns: a scientific journey. Author Shirley Tilghman Publication Year 2014 Type Journal Article Abstract In this perspective I look back on the twists and turns that influenced the direction of my scientific career over the past 40 years. From my early ambition to be a chemist to my training in Philadelphia and Bethesda as a molecular biologist, I benefited enormously from generous and valuable mentoring. In my independent career in Philadelphia and Princeton, I was motivated by a keen interest in the changes in gene expression that direct the development of the mammalian embryo and inspired by the creativity and energy of my students, fellows, and research staff. After twelve years as President of Princeton University, I have happily returned to the faculty of the Department of Molecular Biology. Keywords Repressor Proteins, Animals, Mice, Molecular Sequence Data, Humans, Molecular Biology, Amino Acid Sequence, Embryonic Development, Gene Expression Regulation, Developmental, Canada, Chromosome Walking, Eye Proteins, Genomic Imprinting, History, 20th Century, History, 21st Century, Homeodomain Proteins, National Institutes of Health (U.S.), New Jersey, Paired Box Transcription Factors, RNA Splicing, RNA, Long Noncoding, United States, Universities, alpha-Fetoproteins, beta-Globins, PAX6 Transcription Factor Journal Annu Rev Cell Dev Biol Volume 30 Pages 1-21 Date Published 2014 ISSN Number 1530-8995 DOI 10.1146/annurev-cellbio-100913-013512 Alternate Journal Annu Rev Cell Dev Biol PMID 25288111 PubMedGoogle ScholarBibTeXEndNote X3 XML