Title | A twist in Pitx2 regulation of gut looping. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Menon, T, Burdine, RD |
Journal | Dev Cell |
Volume | 57 |
Issue | 21 |
Pagination | 2445-2446 |
Date Published | 2022 Nov 07 |
ISSN | 1878-1551 |
Keywords | Body Patterning, Gene Expression Regulation, Developmental, Homeodomain Proteins, Signal Transduction, Transcription Factors, Transforming Growth Factor beta |
Abstract | <p>Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a "brake" to counteract BMP4 signaling on the right.</p> |
DOI | 10.1016/j.devcel.2022.10.006 |
Alternate Journal | Dev Cell |
PubMed ID | 36347237 |