| Title | A twist in Pitx2 regulation of gut looping. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Menon, T, Burdine, RD |
| Journal | Dev Cell |
| Volume | 57 |
| Issue | 21 |
| Pagination | 2445-2446 |
| Date Published | 2022 Nov 07 |
| ISSN | 1878-1551 |
| Keywords | Body Patterning, Gene Expression Regulation, Developmental, Homeodomain Proteins, Signal Transduction, Transcription Factors, Transforming Growth Factor beta |
| Abstract | <p>Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a "brake" to counteract BMP4 signaling on the right.</p> |
| DOI | 10.1016/j.devcel.2022.10.006 |
| Alternate Journal | Dev Cell |
| PubMed ID | 36347237 |
