A twist in Pitx2 regulation of gut looping. Author Triveni Menon, Rebecca Burdine Publication Year 2022 Type Journal Article Abstract Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a "brake" to counteract BMP4 signaling on the right. Keywords Signal Transduction, Transcription Factors, Gene Expression Regulation, Developmental, Homeodomain Proteins, Body Patterning, Transforming Growth Factor beta Journal Dev Cell Volume 57 Issue 21 Pages 2445-2446 Date Published 2022 Nov 07 ISSN Number 1878-1551 DOI 10.1016/j.devcel.2022.10.006 Alternate Journal Dev Cell PMID 36347237 PubMedGoogle ScholarBibTeXEndNote X3 XML