A twist in Pitx2 regulation of gut looping.

Author

Triveni Menon, Rebecca Burdine

Publication Year

2022

Type

Journal Article

Abstract

Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a "brake" to counteract BMP4 signaling on the right.

Keywords

Signal Transduction, Transcription Factors, Gene Expression Regulation, Developmental, Homeodomain Proteins, Body Patterning, Transforming Growth Factor beta

Journal

Dev Cell

Volume

Issue

Pages

2445-2446

Date Published

11/2022

ISSN Number

1878-1551