Tumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications. Author Hanqiu Zheng, Wenyang Li, Yibin Kang Publication Year 2016 Type Journal Article Abstract Metastasis and associated complications are the major cause of death for cancer patients. The incidence of bone metastasis is among the highest in cancers arising from breast, prostate, and lung. Common skeletal-related events caused by bone metastasis include aberrant bone remodeling (osteolytic, osteoblastic, and mixed), bone pain, fracture, spinal cord compression, and life-threatening hypercalcemia. It is now known that interactions between tumor cells and bone stroma lie at the core of major steps of bone-metastasis progression. Approved pharmaceutical drugs for the treatment of bone metastasis, including bisphosphonate and denosumab, were designed to target bone stromal cell components. In recent years, research in our laboratory and others has revealed intricate tumor-stroma interactions as the driving force behind osteolytic bone-metastasis development, providing a set of new candidates for future drug development. Moreover, recent studies also indicate existence of distinct bone niches in supporting hematopoietic stem cell renewal and differentiation. These niche components are likely utilized by metastatic cancer cells for seeding, progression, and therapy resistance of bone metastasis. Future studies in this direction may discover additional therapeutic targets for bone-metastasis treatment. Keywords Animals, Humans, Cell Differentiation, Bone Neoplasms, Drug Resistance, Neoplasm, Neoplasm Metastasis, Hematopoietic Stem Cells, Bone Remodeling Journal Cold Spring Harb Symp Quant Biol Volume 81 Pages 151-161 Date Published 2016 ISSN Number 1943-4456 DOI 10.1101/sqb.2016.81.030775 Alternate Journal Cold Spring Harb Symp Quant Biol PMID 28381439 PubMedGoogle ScholarBibTeXEndNote X3 XML