Tumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications.

TitleTumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications.
Publication TypeJournal Article
Year of Publication2016
AuthorsZheng, H, Li, W, Kang, Y
JournalCold Spring Harb Symp Quant Biol
Date Published2016
KeywordsAnimals, Bone Neoplasms, Bone Remodeling, Cell Differentiation, Drug Resistance, Neoplasm, Hematopoietic Stem Cells, Humans, Neoplasm Metastasis

<p>Metastasis and associated complications are the major cause of death for cancer patients. The incidence of bone metastasis is among the highest in cancers arising from breast, prostate, and lung. Common skeletal-related events caused by bone metastasis include aberrant bone remodeling (osteolytic, osteoblastic, and mixed), bone pain, fracture, spinal cord compression, and life-threatening hypercalcemia. It is now known that interactions between tumor cells and bone stroma lie at the core of major steps of bone-metastasis progression. Approved pharmaceutical drugs for the treatment of bone metastasis, including bisphosphonate and denosumab, were designed to target bone stromal cell components. In recent years, research in our laboratory and others has revealed intricate tumor-stroma interactions as the driving force behind osteolytic bone-metastasis development, providing a set of new candidates for future drug development. Moreover, recent studies also indicate existence of distinct bone niches in supporting hematopoietic stem cell renewal and differentiation. These niche components are likely utilized by metastatic cancer cells for seeding, progression, and therapy resistance of bone metastasis. Future studies in this direction may discover additional therapeutic targets for bone-metastasis treatment.</p>

Alternate JournalCold Spring Harb Symp Quant Biol
PubMed ID28381439