A tumor-specific endogenous repetitive element is induced by herpesviruses.

TitleA tumor-specific endogenous repetitive element is induced by herpesviruses.
Publication TypeJournal Article
Year of Publication2019
AuthorsNogalski, MT, Solovyov, A, Kulkarni, AS, Desai, N, Oberstein, A, Levine, AJ, Ting, DT, Shenk, T, Greenbaum, BD
JournalNat Commun
Volume10
Issue1
Pagination90
Date Published2019 01 09
ISSN2041-1723
KeywordsCell Line, Cell Movement, Fibroblasts, Gene Expression Regulation, Herpesviridae, Human Genetics, Humans, In Situ Hybridization, Interspersed Repetitive Sequences, RNA, Up-Regulation
Abstract

Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases.

DOI10.1038/s41467-018-07944-x
Alternate JournalNat Commun
PubMed ID30626867
PubMed Central IDPMC6327058
Grant List1P30CA196521-01 / NH / NIH HHS / United States
R01 AI081848 / AI / NIAID NIH HHS / United States
7R01AI081848-04 / NH / NIH HHS / United States
AI112951 / NH / NIH HHS / United States
R56 AI112951 / AI / NIAID NIH HHS / United States
R01 AI112951 / AI / NIAID NIH HHS / United States
P30 CA196521 / CA / NCI NIH HHS / United States