Title | Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Devenport, D |
Journal | Semin Cell Dev Biol |
Volume | 55 |
Pagination | 99-110 |
Date Published | 2016 07 |
ISSN | 1096-3634 |
Keywords | Actins, Animals, Cell Lineage, Cell Polarity, Humans, Microtubules, Models, Biological, Morphogenesis |
Abstract | <p>The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review.</p> |
DOI | 10.1016/j.semcdb.2016.03.012 |
Alternate Journal | Semin Cell Dev Biol |
PubMed ID | 26994528 |
PubMed Central ID | PMC5005802 |
Grant List | R01 AR066070 / AR / NIAMS NIH HHS / United States |