Tissue morphodynamics: Translating planar polarity cues into polarized cell behaviors.

Publication Year
2016

Type

Journal Article
Abstract

The ability of cells to collectively orient and align their behaviors is essential in multicellular organisms for unidirectional cilia beating, collective cell movements, oriented cell divisions, and asymmetric cell fate specification. The planar cell polarity pathway coordinates a vast and diverse array of collective cell behaviors by intersecting with downstream pathways that regulate cytoskeletal dynamics and intercellular signaling. How the planar polarity pathway translates directional cues to produce polarized cell behaviors is the focus of this review.

Journal
Semin Cell Dev Biol
Volume
55
Pages
99-110
Date Published
2016 Jul
ISSN Number
1096-3634
Alternate Journal
Semin Cell Dev Biol
PMCID
PMC5005802
PMID
26994528