Title | Tissue mechanics regulates form, function, and dysfunction. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Anlas, AA, Nelson, CM |
Journal | Curr Opin Cell Biol |
Volume | 54 |
Pagination | 98-105 |
Date Published | 2018 Oct |
ISSN | 1879-0410 |
Keywords | Animals, Biomechanical Phenomena, Cellular Microenvironment, Epithelial Cells, Humans, Models, Biological, Morphogenesis, Organogenesis |
Abstract | <p>Morphogenesis encompasses the developmental processes that reorganize groups of cells into functional tissues and organs. The spatiotemporal patterning of individual cell behaviors is influenced by how cells perceive and respond to mechanical forces, and determines final tissue architecture. Here, we review recent work examining the physical mechanisms of tissue morphogenesis in vertebrate and invertebrate models, discuss how epithelial cells employ contractility to induce global changes that lead to tissue folding, and describe how tissue form itself regulates cell behavior. We then highlight novel tools to recapitulate these processes in engineered tissues.</p> |
DOI | 10.1016/j.ceb.2018.05.012 |
Alternate Journal | Curr Opin Cell Biol |
PubMed ID | 29890398 |
PubMed Central ID | PMC6214752 |
Grant List | R21 HL110335 / HL / NHLBI NIH HHS / United States R01 CA187692 / CA / NCI NIH HHS / United States R21 HL118532 / HL / NHLBI NIH HHS / United States R01 GM083997 / GM / NIGMS NIH HHS / United States R01 HL120142 / HL / NHLBI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States |