Tissue mechanics regulates form, function, and dysfunction.

TitleTissue mechanics regulates form, function, and dysfunction.
Publication TypeJournal Article
Year of Publication2018
AuthorsAnlas, AA, Nelson, CM
JournalCurr Opin Cell Biol
Volume54
Pagination98-105
Date Published2018 Jun 08
ISSN1879-0410
Abstract

Morphogenesis encompasses the developmental processes that reorganize groups of cells into functional tissues and organs. The spatiotemporal patterning of individual cell behaviors is influenced by how cells perceive and respond to mechanical forces, and determines final tissue architecture. Here, we review recent work examining the physical mechanisms of tissue morphogenesis in vertebrate and invertebrate models, discuss how epithelial cells employ contractility to induce global changes that lead to tissue folding, and describe how tissue form itself regulates cell behavior. We then highlight novel tools to recapitulate these processes in engineered tissues.

DOI10.1016/j.ceb.2018.05.012
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID29890398
Grant ListR21 HL110335 / HL / NHLBI NIH HHS / United States
R01 CA187692 / CA / NCI NIH HHS / United States
R21 HL118532 / HL / NHLBI NIH HHS / United States
R01 GM083997 / GM / NIGMS NIH HHS / United States
R01 HL120142 / HL / NHLBI NIH HHS / United States