Tinker, tailor, antiviral: RNA virus inhibition by induced recombination.

TitleTinker, tailor, antiviral: RNA virus inhibition by induced recombination.
Publication TypeJournal Article
Year of Publication2022
AuthorsPitre, E, Velthuis, AJWTe
JournalTrends Biochem Sci
Volume47
Issue6
Pagination456-458
Date Published2022 Jun
ISSN0968-0004
KeywordsAntiviral Agents, Genome, Viral, Recombination, Genetic, RNA Viruses, RNA, Viral
Abstract

<p>Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.</p>

DOI10.1016/j.tibs.2022.01.003
Alternate JournalTrends Biochem Sci
PubMed ID35123872
Grant List206579/Z/17/Z / WT_ / Wellcome Trust / United Kingdom