| Title | Tinker, tailor, antiviral: RNA virus inhibition by induced recombination. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Pitre, E, Velthuis, AJWTe |
| Journal | Trends Biochem Sci |
| Volume | 47 |
| Issue | 6 |
| Pagination | 456-458 |
| Date Published | 2022 Jun |
| ISSN | 0968-0004 |
| Keywords | Antiviral Agents, Genome, Viral, Recombination, Genetic, RNA Viruses, RNA, Viral |
| Abstract | <p>Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.</p> |
| DOI | 10.1016/j.tibs.2022.01.003 |
| Alternate Journal | Trends Biochem Sci |
| PubMed ID | 35123872 |
| Grant List | 206579/Z/17/Z / WT_ / Wellcome Trust / United Kingdom |
