Title | Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Basurto-Islas, G, Blanchard, J, Tung, YChyn, Fernández, JR, Voronkov, M, Stock, M, Zhang, S, Stock, JB, Iqbal, K |
Journal | Neurobiol Aging |
Volume | 35 |
Issue | 12 |
Pagination | 2701-2712 |
Date Published | 2014 Dec |
ISSN | 1558-1497 |
Keywords | Alzheimer Disease, Animals, Coffee, Disease Models, Animal, Female, Methylation, Neuroprotective Agents, Protein Phosphatase 2, Rats, Rats, Transgenic, Serotonin |
Abstract | <p>A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). In this model, viral expression of the phosphoprotein phosphatase 2A (PP2A) endogenous inhibitor, the I2(PP2A), or SET protein in the brains of rats leads to several characteristic features of AD including cognitive impairment, tau hyperphosphorylation, and elevated levels of cytoplasmic amyloid-β protein. Dietary supplementation with EHT for 6-12 months resulted in substantial amelioration of all these defects. The beneficial effects of EHT could be associated with its ability to increase PP2A activity by inhibiting the demethylation of its catalytic subunit PP2Ac. These findings raise the possibility that EHT may make a substantial contribution to the apparent neuroprotective benefits associated with coffee consumption as evidenced by numerous epidemiologic studies indicating that coffee drinkers have substantially lowered risk of developing AD. </p> |
DOI | 10.1016/j.neurobiolaging.2014.06.012 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 25034344 |
PubMed Central ID | PMC4254318 |
Grant List | R01 AG019158 / AG / NIA NIH HHS / United States R01 AT006868 / AT / NCCIH NIH HHS / United States |