Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.

TitleTherapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2014
AuthorsBasurto-Islas, G, Blanchard, J, Tung, YChyn, Fernández, JR, Voronkov, M, Stock, M, Zhang, S, Stock, JB, Iqbal, K
JournalNeurobiol Aging
Volume35
Issue12
Pagination2701-2712
Date Published2014 Dec
ISSN1558-1497
KeywordsAlzheimer Disease, Animals, Coffee, Disease Models, Animal, Female, Methylation, Neuroprotective Agents, Protein Phosphatase 2, Rats, Rats, Transgenic, Serotonin
Abstract

<p>A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). In this model, viral expression of the phosphoprotein phosphatase 2A (PP2A) endogenous inhibitor, the I2(PP2A), or SET protein in the brains of rats leads to several characteristic features of AD including cognitive impairment, tau hyperphosphorylation, and elevated levels of cytoplasmic amyloid-β protein. Dietary supplementation with EHT for 6-12 months resulted in substantial amelioration of all these defects. The beneficial effects of EHT could be associated with its ability to increase PP2A activity by inhibiting the demethylation of its catalytic subunit PP2Ac. These findings raise the possibility that EHT may make a substantial contribution to the apparent neuroprotective benefits associated with coffee consumption as evidenced by numerous epidemiologic studies indicating that coffee drinkers have substantially lowered risk of developing AD. </p>

DOI10.1016/j.neurobiolaging.2014.06.012
Alternate JournalNeurobiol. Aging
PubMed ID25034344
PubMed Central IDPMC4254318
Grant ListR01 AG019158 / AG / NIA NIH HHS / United States
R01 AT006868 / AT / NCCIH NIH HHS / United States